5915 Landerbrook Dr, Ste 110   |   Mayfield Heights, OH44124   |   Phone: 216-381-3333   |   Fax: 440-443-0700   |   ois@allergycleveland.com
Top Rated Allergists & Asthma Specialists in Cleveland & Northeast Ohio
Top Rated Allergists & Asthma Specialists in Cleveland & Northeast Ohio

Rituxan Biologic Infusion Therapy

What conditions does Rituxan treat?

Rituxan (rituximab) is a biologic drug therapy used to treat adults with: 

  • Rheumatoid arthritis (RA) (with methotrexate treatment) 
  • Non-Hodgkin’s lymphoma (NHL) (alone or with chemotherapy treatments) 
  • Chronic lymphocytic leukemia (CLL) (with chemotherapy medicines fludarabine and cyclophosphamide) 
  • Granulomatosis with polyangiitis (GPA) and ​microscopic polyangiitis (MPA) in patients ages 2 years and older (with glucocorticoids) 
  • Moderate to severe​ pemphigus vulgaris (PV) 

How does Rituxan work?


A common RA treatment is a class of biologic drugs called anti-TNFs, which stands for anti-tumor necrosis factor. Anti-TNFs block the excess production of TNF-alpha proteins, which can cause the joint inflammation associated with RA. Unlike anti-TNFs, B-cell therapy targets a type of white blood cell called a B-cell, which is believed to play a role in the symptoms and joint damage of RA. Currently, Rituxan in combination with methotrexate is the only B-cell therapy approved to treat RA. 


Rituxan targets and attaches to the CD20 protein found on the surface of both NHL and CLL cells and some healthy blood cells. Once attached to the CD20 protein, Rituxan helps your own immune system destroy the cancer cells and/or destroys the cancer cells on its own. 


These are considered to be forms of ANCA-associated vasculitis (blood vessel inflammation), referring to a blood protein called anti-neutrophil cytoplasmic antibody that attacks the body’s own cells and tissues. ANCAs are produced by B-cells and cause another type of white blood cells called neutrophils to inflame blood vessel walls. Rituxan interferes with and decreases the number of B-cells, which is thought to disrupt ANCA production. 


Rituxan binds specifically to the CD20 protein present only on certain B-cell populations. This helps prevent B-cells from producing antibodies against the molecules in the epidermis that help glue skin cells together, thus reducing the amount of skin lesions and blisters. 

How is Rituxan administered?

Rituxan is administered intravenously. The dose amount and frequency depend on the age of the patient and their individual diagnosis. 

Click here to view the pharmaceutical website for Rituxan. 

Rituxan Financial Assistance

This product may be used to treat other conditions, not listed here. If you are currently using or have a physician’s order to begin using this product for an unlisted condition and you have questions related to whether or not we can offer you infusion services,  please call our office or fill out a form and a member of our team will reach out to you as soon as possible