5915 Landerbrook Dr, Suite 110   |   Mayfield Heights, OH44124   |   Phone: 216-381-3333   |   Fax: 440-443-0700   |   ois@allergycleveland.com

Top Rated Allergists & Asthma Specialists in Cleveland & Northeast Ohio

Xolair Injection Therapy

What is Xolair?

Xolair (omalizumab) is a biologic drug therapy that is an add-on medication used to treat allergic asthma (AA) in patients aged 6 years and older that is not controlled by inhaled corticosteroids (ICS), and ​chronic spontaneous urticaria (chronic hives) in patients aged 12 years and older that is not controlled with H1 antihistamine treatment. 

How does Xolair work?

Allergic Asthma

In response to breathing in an airborne allergen, the body makes a substance called IgE (immunoglobulin E). The IgE then attaches itself to both the allergen and the inflammatory cell, which releases a substance that may cause inflammation in the airways and lead to an asthma attack. Xolair prevents IgE from binding to the inflammatory cell, which is thought to help reduce asthma symptoms and attacks. 

Chronic Spontaneous Urticaria

Mast cells are found in almost all of the body’s tissues, including the skin. IgE attaches to receptors on mast cells, triggering the release of histamine and other inflammatory chemicals under certain conditions. (Histamine causes inflammation that leads to hives and itching associated with CSU.) Xolair binds to IgE before it can attach to mast cells and also reduces the number of IgE receptors on the surface of mast cells. 

How is Xolair administered?

Xolair is administered via injection. Doses are given once every 2 to 4 weeks. For AA patients, the dose (mg) and dosing frequency are determined by serum total IgE level (IU/mL), measured before the start of treatment, and body weight (kg). 

Click here to visit the pharmaceutical website for Xolair.

Xolair patient Assistance program

This product may be used to treat other conditions not listed. If you are currently using or have a physician’s order to begin using this product for an unlisted condition and you have questions about whether or not we can offer you infusion services, please call our office or fill out a form and a member of our team will reach out to you as soon as possible.

If you’d like more information about the other treatment options we offer, please visit the IVIg infusions or IV infusions pages to learn more.